Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity
نویسندگان
چکیده
منابع مشابه
The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance
Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases. Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Recent studies have proposed a close relat...
متن کاملRegulation of obesity and insulin resistance by hypoxia-inducible factors
In obesity, dysregulated metabolism and aberrant expansion of adipose tissue lead to the development of tissue hypoxia that plays an important role in contributing to obesity-associated metabolic disorders. Recent studies utilizing adipocyte-specific hypoxia-inducible factor-α (HIF-α) gain- or loss-of-function animal models highlight the pivotal involvement of hypoxic responses in the pathogene...
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Adipose tissue hypoxia and inflammation have been causally implicated in obesity-induced insulin resistance. Here, we report that, early in the course of high-fat diet (HFD) feeding and obesity, adipocyte respiration becomes uncoupled, leading to increased oxygen consumption and a state of relative adipocyte hypoxia. These events are sufficient to trigger HIF-1α induction, setting off the chron...
متن کاملPrevalence of Obesity, Dyslipidemia, and Insulin Resistance in Childhood Cancer Survivors
Background: With the increased survival rates following the treatment of childhood cancer, it becomes equally important that the need for evidence based surveillance of long term effects of cancer therapy is addressed. This includes the risk of development of metabolic syndrome features like obesity, altered lipid and sugar profile, which was attempted in the present study. Materials and Metho...
متن کاملThe role of adipocyte insulin resistance in the pathogenesis of obesity-related elevations in endocannabinoids.
OBJECTIVE Obesity is associated with an overactive endocannabinoid (EC) system. The mechanisms responsible for increased ECs in obese individuals are poorly understood. Therefore, we examined the role of adipocyte insulin resistance in intracellular EC metabolism. METHODS We used 3T3-L1 adipocytes and diet-induced obese (DIO) mice to examine the role of obesity and insulin resistance in the r...
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ژورنال
عنوان ژورنال: Nature Metabolism
سال: 2018
ISSN: 2522-5812
DOI: 10.1038/s42255-018-0003-x